protagonist Icchapurapu Amrutha Rao in the long-running television sitcom *Amrutham* (2001–2007), a role he later reprised in its digital sequel *Amrutham Dhvitheeyam* (2020). Concurrently, he established a prolific career as a character actor, appearing in features including *Aithe* (2003), *Anukokunda Oka Roju* (2005), *Leader* (2010), *Ala Vaikunthapurramuloo* (2020), and *Saripodhaa Sanivaaram* (2024).

In addition to acting, Vardhan transitioned into screenwriting, providing dialogues for the thriller *Vishaka Express* (2008) and the sports drama *Guru* (2017). He gained notable industry recognition for writing the screenplay for the romantic comedy *Gunde Jaari Gallanthayyinde* (2013) and the dialogues for the fantasy drama *Manam* (2014). In 2023, he made his feature directorial debut with the action comedy *Maama Mascheendra*, which he also wrote. His subsequent acting credits include the streaming series *Save the Tigers* (2023), the drama *Court: State vs. A Nobody* (2025), and *Mana ShankaraVaraPrasad Garu* (2026).